Lithium hydroxide, monohydrate → 3-((6-Aminopyridin-3-yl)carbamoyl)-4-methylbenzoic acid

Participants

Reaction Steps

To methyl 3-((6-aminopyridin-3-yl)carbamoyl)-4-methylbenzoate (0.11 g, 0.39 mmol) dissolved in tetrahydrofuran (1.5 mL) was added a solution of lithium hydroxide, monohydrate (24 mg, 0.58 mmol) in water (1.5 mL). The reaction mixture was stirred at RT for 4 h. THF was removed in vacuo and to the aqueous layer was added 2N HCl until pH 4-5. The precipitate formed was collected by filtration, washed with water, dried to give 3-((6-aminopyridin-3-yl)carbamoyl)-4-methylbenzoic acid as a tan solid, MS (ESI, pos. ion) m/z: 272.1 (M+1).

Provenance & Evidence