Potassium Carbonate → HCID 68453947, compound

Participants

Reaction Steps

A mixture of 6-[2-(2-butyl-1-benzofuran-3-yl)-1,3-oxazol-5-yl]-2-naphthol (1.29 g, 3.37 mmol), prepared in the previous step, bromoacetonitrile (282 μL, 4.05 mmol) and of potassium carbonate (2.33g, 16.8 mmol) in 100 mL of DMF was stir under nitrogen overnight at room temperature. The reaction was diluted with ethyl acetate, extracted three times with water, dried (MgSO4), filtered and the solvent was removed under reduced pressure to give ({6-[2-(2-butyl-1-benzofuran-3-yl)-1,3-oxazol-5-yl]-2-naphthyl}oxy)acetonitrile (1.12 g, 79%) as a white solid, mp 127-127° C. Elemental Analysis for C27H22N2O3 Calc'd: C, 76.76; H, 5.25; N, 6.63. Found: C, 76.53; H, 5.22; N, 6.59.

Provenance & Evidence