Hydrochloric Acid → HCID 11678167, compound

Participants

Reaction Steps

A mixture of methyl 2-({6-[2-(2-butyl-1-benzofuran-3-yl)-1,3-oxazol-5-yl]-2-naphthyl}oxy)-3-phenylpropanoate (346 mg, 0.633 mmol), prepared in the previous step, and 1 N NaOH (1.26 mL, 1.26 mmol) in 50 mL of THF was stirred at room temperature for 18 h (overnight). The reaction was acidified by the addition of 1.4 mL of 1N HCl and then concentrated under reduced pressure to remove the THF. The yellow solid that formed was collected by filtration, rinsed with water and dried under reduced pressure to give the title compound (266 mg, 77%) as a yellow solid, mp 174-177° C. Elemental Analysis for C34H29NO5+0.039 H2O Calc'd: C, 76.72; H, 5.51; N, 2.63. Found: C, 75.36; H, 5.48; N, 2.44.

Provenance & Evidence