Hydrochloric Acid → HCID 11721062, compound

Participants

Reaction Steps

A mixture of methyl 2-({6-[2-(1-benzyl-1H-indol-3-yl)-1,3-oxazol-5-yl]-2-naphthyl}oxy)-3-phenylpropanoate (117 mg 0.202 mmol), prepared in the previous step, and 1 N NaOH (400 μL, 0.4 mmol) in 20 mL of THF was stirred at room temperature for 16 hr (overnight). The reaction was acidified by the addition of 500 μL of 1N HCl and then concentrated under reduced pressure to remove the THF. The yellow solid that formed was collected by filtration, rinsed with water and dried under reduced pressure to give the title compound (102 mg, 90%) as a dark yellow solid, mp 125-127° C. Elemental Analysis for C37H28N2O4+0.17 mole of H2O Calc'd: C, 78.28; H, 5.03; N, 4.93. Found: C, 76.56; H, 5.59; N, 4.37.

Provenance & Evidence