Hydrochloric Acid → HCID 11634262, compound

Participants

Reaction Steps

A mixture of methyl ({6-[2-(1-benzyl-1H-indol-3-yl)-1,3-oxazol-5-yl]-2-naphthyl}oxy)acetate (271 mg, 0.555 mmol), prepared in the previous step, and 1N NaOH (1.11 mL, 1.11 mmol) in 35 mL of THF plus 20 mL of H2O was stirred at room temperature for 15 h (overnight). The reaction was acidified by the addition of 1.2 mL of 1N HCl and then concentrated under reduced pressure to remove the THF. The white solid that formed was collected by filtration, rinsed with water and dried under reduced pressure to give the title compound (236 mg, 90%) as a white solid, mp 238-242° C. Elemental Analysis for C30H22N2O4+0.32 mole of H2O. Calc'd: C, 75.03; H, 4.75; N, 5.83. Found: C, 74.67; H, 5.34; N, 5.19.

Provenance & Evidence