Hydrochloric Acid → HCID 11682723, compound

Participants

Reaction Steps

A mixture of methyl ({6-[2-(1-methyl-1H-indol-3-yl)-1,3-oxazol-5-yl]-2-naphthyl}oxy)acetate (254 mg, 0.925 mmol), prepared in the previous step, and 1N NaOH (925 μL, 0.925 mmol) in 30 mL of THF, 30 mL of methanol and 10 mL of H2O was stirred at room temperature for 16 h (overnight). The reaction was acidified by the addition of 1.0 mL of 1N HCl and then concentrated under reduced pressure to remove the THF and methanol. The yellow solid that formed was collected by filtration, rinsed with water and dried under reduced pressure to give the title compound (218 mg, 89%) as a yellow solid, mp 269-272° C. Elemental Analysis for C24H18N2O4 Calc'd: C, 72.35; H, 4.55; N, 7.03. Found: C, 71.97; H, 4.78; N, 6.73.

Provenance & Evidence