HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → HCID 23133517, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-(3-Aminopropyl)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl} sulfonyl)methyl] imidazolidine-2,4-dione trifluoroacetic acid | HCID 66851209 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 23133517 | HCID 23133517 | — |
Reaction Steps
5-(3-Aminopropyl)-5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]imidazolidine-2,4-dione trifluoroacetic acid (100 mg, 0.18 mmol) was slurried in 2 mL DCM. DIPEA (624 μL, 0.36 mmol) was added and the slurry was stirred for some minutes. Sulfonylchloride (16 μL, 0.18 mmol) was added and the reaction was stirred at rt over night. The crude product was purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754750B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-685f2d9e0d264a9f93357aaed6336c62 |
| Source note | uspto-grants-2010_07 |