HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile → (2S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.1]hept-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile | HCID 11031276 | — |
| Reactant | Ethyl 4-aminobicyclo[2.2.1]heptane-1-carboxylate | HCID 23149671 | — |
| Product | (2S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.1]hept-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile | HCID 59383138 | 91.1% |
Reaction Steps
In a similar manner to Example 6, ethyl 4-aminobicyclo[2.2.1]heptane-1-carboxylate (50.0 mg) and (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile (59.3 mg) were used to obtain (2S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.1]hept-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile (79.4 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754757B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-055be4f2a5d0495bbd9da2c9c599a590 |
| Source note | uspto-grants-2010_07 |