1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 59383139, compound

Participants

Role	Name	HCID	Charge
Reactant	1-(Bromomethyl)-4-(trifluoromethyl)benzene	HCID 123062	—
Reactant	(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile	HCID 57634365	—
Product	HCID 59383139	HCID 59383139	74.5%

Reaction Steps

In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (20.0 mg) and 4-trifluoromethylbenzyl bromide (16.2 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(4-trifluoromethylbenzyl)oxycarbonyl bicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (22.2 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07754757B2
Source dataset	uspto-grants-2010_07
ORD ID	ord-4a4ccf26b5e2478580575200b9cbf1c1
Source note	uspto-grants-2010_07