HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyloxybenzyl chloride → HCID 59383151, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 59383151 | HCID 59383151 | 72.4% |
Reaction Steps
In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (30.0 mg) and 4-methoxybenzyl chloride (16.0 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(4-methoxybenzyl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (29.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754757B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-cfe3fee714cf4b189671a4ae0ff9529d |
| Source note | uspto-grants-2010_07 |