4-Toluenesulfonyl chloride → HCID 86612270, compound

Participants

Reaction Steps

In step 8, a ring closure is effected by treatment of diol s with palladium diacetate in the presence of 2[P(t-Bu)2]-1,1-binaphthyl, to afford chroman compound t. Chroman t is treated with tosyl chloride to form chroman tosylate u in step 9. In step 10, tosylate u is reacted with amine v to afford chroman w, which is a compound of formula I in accordance with the invention.

Provenance & Evidence