HCID 58869132, compound → HCID 58869192, compound

Participants

Reaction Steps

To a solution of (7-benzenesulfonyl-4-oxo-chroman-2-ylmethyl)-methyl-carbamic acid tert-butyl ester (216 mg, 0.5 mmol) in MeOH (40 mL) was added Pd/C (10%, 20 mg) and the mixture was stirred under balloon pressure of H2 overnight. The reaction was filtered through a celite pad and the filtrate was concentrated in vacuo. The residue was purified via flash chromatography (DCM/MeOH, 99/1) to give (7-benzenesulfonyl-4-hydroxy-chroman-2-ylmethyl)-methyl-carbamic acid tert-butyl ester (159 mg, 74% yield).

Provenance & Evidence