HCID 58869132, compound → HCID 58869160, compound

Participants

Reaction Steps

To a solution of (7-benzenesulfonyl-4-oxo-chroman-2-ylmethyl)-methyl-carbamic acid tert-butyl ester (216 mg, 0.5 mmol) in THF (25 mL) at 0° C. was added MeMgCl (3.0 M in THF, 0.208 mL). The mixture was allowed to warm at room temperature and was stirred for 6 hours. The reaction was quenched by addition of water and it was concentrated in vacuo. The aqueous residue was extracted with DCM and the organic extracts were dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified via flash chromatography (DCM/MeOH, 97/3) to give (7-benzenesulfonyl-4-hydroxy-4-methyl-chroman-2-ylmethyl)-methyl-carbamic acid tert-butyl ester (214 mg, 96% yield) as yellow crystalline solid.

Provenance & Evidence