Boron trifluoride etherate → HCID 58869153, compound

HRID 2355212Notes

Reaction equation

HRID 2355212 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH:18](O)[CH2:19][Si](C)(C)C)=[C:12]([Br:25])[CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B(F)(F)F.CCOCC>C(Cl)Cl>[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH:18]=[CH2:19])=[C:12]([Br:25])[CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 8000Boron trifluoride etherateHCID 66917402HCID 66917402, compound

Product 1

HCID 58869153HCID 58869153, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 4-(4-benzenesulfonyl-2-bromo-phenyl)-1-trimethylsilanyl-butan-2-ol (4.38 g) in DCM (80 mL) was added BF3.OEt2 (3.76 mL) at 0° C. under N2 atmosphere. The reaction was stirred at 0° C. for 1 h it was then quenched by addition of NaHCO3 (saturated solution). The mixture was extracted twice with DCM and the combined extracts were washed with water, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified via flash chromatography (hexane/EtOAc, 9/1) to afford 4-benzenesulfonyl-2-bromo-1-but-3-enyl-benzene (3.38 g, 93% yield).

Workup

  1. customwas then quenched by addition of NaHCO3 (saturated solution)
  2. extractionThe mixture was extracted twice with DCM
  3. washthe combined extracts were washed with water
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified via flash chromatography (hexane/EtOAc, 9/1)

Sources & evidence

ORD record
ord-b15589c765b6444782507b5eb4e3f507
Source dataset
uspto-grants-2010_07
Patent number
US07754759B2

Reaction notes

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