HCID 58869134, compound → HCID 16058708, compound

HRID 2355217Notes

Reaction equation

HRID 2355217 reaction equation
C1(S(C2C=CC(CC[C@@H](O)CO)=C(Br)C=2)(=O)=O)C=CC=CC=1.[C:23]1([S:29]([C:32]2[CH:41]=[C:40]3[C:35]([CH2:36][CH2:37][C@H:38]([CH2:42][NH:43][CH3:44])[O:39]3)=[CH:34][CH:33]=2)(=[O:31])=[O:30])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([S:29]([C:32]2[CH:41]=[C:40]3[C:35]([CH2:36][CH2:37][C@@H:38]([CH2:42][NH:43][CH3:44])[O:39]3)=[CH:34][CH:33]=2)(=[O:31])=[O:30])[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 58869134HCID 58869134, compoundHCID 66917418HCID 66917418, compound

Product 1

HCID 16058708HCID 16058708, compound

Procedure

((S)-7-Benzenesulfonyl-chroman-2-ylmethyl)-methyl-amine was prepared as a hydrochloride salt following the procedure described for the corresponding (R) enantiomer in step 10 of Example 6, but substituting ((S)-7-benzenesulfonyl-chroman-2-ylmethyl)-methyl-amine for ((R)-7-benzenesulfonyl-chroman-2-ylmethyl)-methyl-amine: Mp 270.0-270.4° C.

Sources & evidence

ORD record
ord-bd1c27b57d004bfd8678b694cde07dda
Source dataset
uspto-grants-2010_07
Patent number
US07754759B2

Reaction notes

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