HCID 58869127, compound → HCID 58869130, compound

Participants

Reaction Steps

To a solution of C—[(R)-7-(3-fluoro-benzenesulfonyl)-chroman-2-yl]-methyl azide (1.76 g, 5.07 mmol) in 30 mL of THF was added 10% Pd/C (0.176 g). The reaction mixture was hydrogenated at 1.5 atmospheric pressure of hydrogen for 18 hours. The mixture was filtered and the filtrated was evaporated under reduced pressure. The residue was purified by flash chromatography (methylene chloride/MeOH 7:3) to give 1.53 g (94%) of C—[(R)-7-(3-Fluoro-benzenesulfonyl)-chroman-2-yl]-methylamine. MP=257.1-258.9° C.; MS (M+H)=322.

Provenance & Evidence