(R)-N-(7-benzenesulfonyl-chroman-2-ylmethyl)-2-benzyloxy-acetamide → (R)-N-(7-Benzenesulfonyl-chroman-2-ylmethyl)-2-hydroxy-acetamide

Participants

Reaction Steps

(R)—N-(7-Benzenesulfonyl-chroman-2-ylmethyl)-2-benzyloxy-acetamide (100 mg, 0.22 mmol) and Perlman's catalyst (12 mg) were added to 15 mL MeOH and hydrogenated for 18 hours at 1.5 atmospheres of hydrogen. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography to give 18.7 g of (R)—N-(7-Benzenesulfonyl-chroman-2-ylmethyl)-2-hydroxy-acetamide, MS (M+H)=362.

Provenance & Evidence