2,2,2-Trifluoro-1-(1H-indol-5-yl)ethan-1-one → HCID 58875123, compound

HRID 2355243Notes

Reaction equation

HRID 2355243 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)=[O:4].C(OC([N:23]1[C:28]([CH3:30])([CH3:29])[CH2:27][CH2:26]OS1(=O)=O)=O)(C)(C)C>>[NH2:23][C:28]([CH3:30])([CH3:29])[CH2:27][CH2:26][N:10]1[C:11]2[C:7](=[CH:6][C:5]([C:3](=[O:4])[C:2]([F:1])([F:14])[F:15])=[CH:13][CH:12]=2)[CH:8]=[CH:9]1

Participants

3

Reactant 2

HCID 450811092,2,2-Trifluoro-1-(1H-indol-5-yl)ethan-1-oneHCID 59383129HCID 59383129, compound

Product 1

HCID 58875123HCID 58875123, compound

Procedure

Prepared analogously to Component V by alkylation of 2,2,2-trifluoro-1-(1H-indol-5-yl)-ethanone with N-tert-butoxycarbonyl-4,4-dimethyl-[1,2,3]oxathiazinane-2,2-dioxide (Component XI) and subsequent cleaving of the acid protecting group.

Workup

  1. customPrepared analogously

Sources & evidence

ORD record
ord-dec5b41c0e1d4450b8af7e5b62e0f75d
Source dataset
uspto-grants-2010_07
Patent number
US07754756B2

Reaction notes

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