Tributyltin azide → HCID 178446083, compound

Participants

Reaction Steps

150 mg (0.30 mmol) N-(3-{(R)-2-[3-(5-cyano-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide (Example 1) are dissolved in 5 ml of toluene and combined with 98 μl (0.36 mmol) tributyltin azide. Then the reaction solution is refluxed for 18 hours. Another 164 μl (0.6 mmol) tributyltin azide are added. The mixture is refluxed for a further 36 hours. Then the solvent is eliminated in vacuo and the residue is chromatographed on silica gel (DCM/methanol/NH4OH=100:0:0→70:30:0.3).

Provenance & Evidence