Isopropanol → HCID 16660492, compound

Participants

Reaction Steps

240 mg (0.36 mmol) methyl 1-{3-[(R)-2-[3-(phenylsulphonylamino)-phenyl]-2-hydroxy-ethylamino]-3-methyl-butyl}-1H-indole-5-carboxylate (Example 5) are dissolved in 5 ml 2-propanol and combined with 19 mg (0.36 mmol) sodium methoxide. The mixture is stirred for 17 hours at ambient temperature and then acidified with TFA while cooling with ice. Then the solvent is eliminated in vacuo and the residue is chromatographed on Microsorb C18-reverse-phase [acetonitrile (0.1% TFA)/water (0.13% TFA)=10:90→100:0].

Provenance & Evidence