1-Butanol → HCID 16660491, compound

HRID 2355249Notes

Reaction equation

HRID 2355249 reaction equation
[C:1]1([S:7]([NH:10][C:11]2[CH:12]=[C:13]([C@@H:17]([OH:38])[CH2:18][NH:19][C:20]([CH3:37])([CH3:36])[CH2:21][CH2:22][N:23]3[C:31]4[C:26](=[CH:27][C:28]([C:32]([O:34][CH3:35])=[O:33])=[CH:29][CH:30]=4)[CH:25]=[CH:24]3)[CH:14]=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+].[CH2:42](O)[CH2:43][CH2:44]C>>[C:1]1([S:7]([NH:10][C:11]2[CH:12]=[C:13]([C@@H:17]([OH:38])[CH2:18][NH:19][C:20]([CH3:36])([CH3:37])[CH2:21][CH2:22][N:23]3[C:31]4[C:26](=[CH:27][C:28]([C:32]([O:34][CH2:35][CH2:42][CH2:43][CH3:44])=[O:33])=[CH:29][CH:30]=4)[CH:25]=[CH:24]3)[CH:14]=[CH:15][CH:16]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 2631-ButanolHCID 10942334Sodium MethoxideHCID 16660494HCID 16660494, compound

Product 1

HCID 16660491HCID 16660491, compound

Procedure

Prepared analogously to Example 7 by reacting methyl 1-{3-[(R)-2-[3-(phenylsulphonylamino)-phenyl]-2-hydroxy-ethylamino]-3-methyl-butyl}-1H-indole-5-carboxylate with sodium methoxide in n-butanol.

Workup

  1. customPrepared analogously to Example 7

Sources & evidence

ORD record
ord-2ccab8881f3f4300a9d3433b98e2f6cd
Source dataset
uspto-grants-2010_07
Patent number
US07754756B2

Reaction notes

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