Potassium Bicarbonate → HCID 58875096, compound

Participants

Reaction Steps

Potassium hydrogen carbonate (331 mg, 3.30 mmol) and 4-bromomethyl-5-methyl-[1,3]dioxol-2-one (Chem. Pharm. Bull. 1984, vol. 32 (6), page 2241-2248) (505 mg, 2.36 mmol) are added to a solution of 1-{3-[(R)-2-[3-(phenylsulphonylamino)-phenyl]-2-hydroxy-ethylamino]-3-methyl-butyl}-1H-indole-5-carboxylic acid-hydrotrifluoroacetate (Example 6; 1.0 g, 1.57 mmol) in 10 ml DMF. Then the reaction mixture is stirred for 18 hours at RT. Then the solid is filtered off and the filtrate is freed from the solvent in vacuo. The residue is chromatographed on silica gel (DCM/methanol/ammonia=100:0:0→90:10:0.1).

Provenance & Evidence