HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 4-cyano-2-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 4-Cyano-2-fluorobenzoic acid | HCID 590659 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-cyano-2-fluorobenzoate | HCID 15278726 | 62.8% |
Reaction Steps
Add 4N hydrochloride in 1,4-dioxane (100 mL, 400 mmol) to 4-cyano-2-fluoro-benzoic acid (10.0 g, 60.5 mmol) in methanol (100 mL). Stir the reaction mixture at room temperature overnight. Concentrate the reaction mixture. Purify the residue by column chromatography (silica gel) eluting with 20% ethyl acetate/hexane to give the title compound (6.8 g, 38.0 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754742B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-47a78e55036f476db708790975ee9366 |
| Source note | uspto-grants-2010_07 |