Triethylamine → HCID 59153165, compound

Participants

Reaction Steps

Mix 1-[4-(4-aminomethyl-benzyloxy)-2-hydroxy-3-trifluoromethyl-phenyl]-3-methyl-butan-1-one hydrochloride (120 mg, 287.2 μmol), 1-methyl-1-H-imidazole-4-carboxylic acid (43.5 mg, 344.6 μmol), 1-hydroxybenzotriazole hydrate (52.8 mg, 344.6 μmol) in anhydrous tetrahydrofuran (4.5 mL). Add triethylamine (72.7 mg, 718 μmol, 100 μL) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (66.1 mg, 344.6 μmol) to the mixture. Stir the reaction mixture at room temperature overnight. Dilute the reaction mixture with water. Extract the mixture with ethyl acetate (3×). Combine the organic layers, wash with brine, dry over sodium sulfate, and concentrate under reduced pressure. Purify the crude residue by flash chromatography (silica gel) eluting with 5% methanol/ethyl acetate followed by reverse phase chromatography using 90/10 to 20/80 (water/0.1% trifluoroacetic acid)/acetonitrile to provide the product as a white solid (75 mg, 153 μmol, 53.4% yield). MS (m/z): 490 (M+1).

Provenance & Evidence