Water → HCID 86626185, compound

Participants

Reaction Steps

To a solution of (S)-tert-butyl 1-(4,4-difluorocyclohexyl)-3-hydroxypropan-2-ylcarbamate (25.7 g, 0.088 mol) in dry CH2Cl2 (300 mL) was added Et3N (35.4 g, 46.2 mL) at 0 to −5° C. A solution of methanesulfonyl chloride (20.1 g, 0.1754 mol) in dry CH2Cl2 (150 mL) was added dropwise at the same temperature. After addition, the mixture was allowed to warm to rt gradually. 300 mL of water was added and the aqueous layer was extracted with CH2Cl2 (3×100 mL). The combined organic layers were washed with 10% aq citric acid, satd aq NaHCO3 and brine, dried over Na2SO4, filtered and concentrated to give methanesulfonic acid (S)-2-(tert-butoxycarbonylamino)-3-(4,4-difluorocyclohexyl)propyl methanesulfonate (28.8 g, 89%), which was used in the next step without purification. 1H NMR (400 MHz, CDCl3): 4.57 (d, J=6.8 Hz, 1H), 4.27 (m, 1H), 4.16 (m, 1H), 3.97 (m, 1H), 3.03 (s, 3H), 2.40-1.20 (m, 11H), 1.44 (s, 9H); MS (E/Z): 372 (M+H+).

Provenance & Evidence