Dimethylamine → HCID 15030061, compound

Participants

Reaction Steps

Solid EDC.HCl (4.62 g, 24.1 mmol) was added to a solution of (S)-2-(tert-butoxycarbonylamino)-3-cyclohexylpropanoic acid (5.08 g, 19.0 mmol), diisopropylethylamine (10.0 mL, 57 mmol), HOBt (0.38 g, 2.8 mmol), DMAP (0.16 g, 1.3 mmol), dimethylamine (15 mL of a 2 M THF solution, 30 mmol), and anhydrous DMF (50 mL). The resultant clear light yellow solution was stirred at rt and the reaction progress was followed by LC-MS. After 5 h, the solvent was removed (50° C., 150 Torr). The residue was taken up in ether (200 mL) and washed with satd aq NaHCO3 (3×25 mL). Hexanes (100 mL) was added to the Et2O extract and this was washed with water (5×10 mL) and brine (3×10 mL), dried (Na2SO4), decanted and stripped. The crude material was purified using 40 g SiO2 with an eluent of hexanes to EtOAc. Combining appropriate fractions and removal of solvent gave (S)-tert-butyl 3-cyclohexyl-1-(dimethylamino)-1-oxopropan-2-ylcarbamate (3.85 g, 69%) as a white solid. MS ESI+ve m/z 321 (M+Na)+.

Provenance & Evidence