Water → HCID 57544575, compound

Participants

Reaction Conditions

Reaction Steps

A 1 M solution of LiAlH4 in THF (2.5 mL, 2.5 mmol) was added to a solution of (S)-tert-butyl 1-(butylamino)-3-cyclohexyl-1-oxopropan-2-ylcarbamate (384.7 mg, 1.18 mmol) in THF (10 mL) at 0° C. The reaction was permitted to warm to 25° C. and stirred for 12 h. The reaction was cooled to 0° C., and H2O (0.2 mL) and then 1 N NaOH (0.2 mL) were introduced with cautious dropwise addition maintaining the temperature below 10° C. The resulting gel was filtered through a pad of Celite and the solids were washed with Et2O (50 mL). The solvent was removed to yield crude (2S)-2-(tert-butoxycarbonylamino)-1-butylamino-3-cyclohexylpropane (312.8 mg, 85%) as a white solid. MS ESI+ve m/z 313 (M+1). The crude amine was used without further purification.

Provenance & Evidence