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HRID2355355

反应详情

EQUATION

反应方程式

HRID 2355355 的结构方程式

REACTANTS

反应物

1
结构：COCCCOC(c1ccccc1)C1CCCN(C(=C[N+](=O)[O-])N[C@H](CNC(=O)OC(C)(C)C)CC2CCCCC2)C1
HCID86626193

未命名化合物

PRODUCTS

生成物

1
结构：COCCCOC(c1ccccc1)C1CCCN(C(=C[N+](=O)[O-])N[C@H](CN)CC2CCCCC2)C1
HCID68708709

未命名化合物

收率 126.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl.O=C(O)C(F)(F)F
溶剂HCID21863450

未命名化合物

PROCEDURE

实验过程

Tert-butyl (S)-2-(1-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)-2-nitrovinylamino)-3-cyclohexylpropylcarbamate (12 mg, 0.02 mmol) was dissolved in 1:1 TFA/CH2Cl2 (3 mL) and stirred for 30 min at rt. LC-MS showed the reaction was complete. After concentration, the mixture was purified by prep HPLC to afford (2S)—N2-(1-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)-2-nitrovinyl)-3-cyclohexylpropane-1,2-diamine (12.4 mg, 68%). LC-MS (3 min) tR=1.38 min. m/z 489 (M+1).

WORKUP

后处理

  1. concentrationAfter concentration
  2. customthe mixture was purified by prep HPLC