1-(2-Iodophenoxy)-2-nitrobenzene → HCID 43479596, compound

Participants

Reaction Steps

A solution of 1-(2-iodophenoxy)-2-nitrobenzene (9.60 g, 28.1 mmol) and SnCl.2H2O (13.0 g, 56.0 mmol) in ethanol (25 mL) and water (5 mL) was refluxed until no starting material remained (˜1 h). The ethanol was removed in vacuo and the aq layer was basified to pH>10 and extracted with CH2Cl2 (4×10 mL). The combined organic layers were dried over Na2SO4, and the solvent was removed to give a crude 2-(2-Iodophenoxy)benzenamine (8.57 g, 98%), which was used for the next step without purification.

Provenance & Evidence