HCID 59382877, compound → HCID 59383036, compound

HRID 2355403Notes

Reaction equation

HRID 2355403 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]([CH:11]1[CH2:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]1)([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH3:9]>C(O)(C(F)(F)F)=O.ClCCl>[F:25][C:2]([F:1])([F:24])[C:3]([CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1)([OH:10])[CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH3:9]

Participants

3

Reactant 1

HCID 59382877HCID 59382877, compound

Product 1

HCID 59383036HCID 59383036, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Tert-butyl 3-(1,1,1-trifluoro-2-hydroxy-6-methoxyhexan-2-yl)piperidine-1-carboxylate (20 mg) was dissolved in 1:1 TFA/dichloromethane (4 mL). The mixture was stirred for 30 min. The mixture was concentrated to afford 1,1,1-trifluoro-6-methoxy-2-(piperidin-3-yl)hexan-2-ol which was used without purification.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-0bb204487d874801a9693208b1af2e5c
Source dataset
uspto-grants-2010_07
Patent number
US07754737B2

Reaction notes

Loading…