Ethanaminium, N,N,N-triethyl-, fluoride (1:1) → HCID 57544655, compound

Participants

Reaction Steps

A solution of 2-(trimethylsilyl)ethyl (S)-3-(4-((tert-butyldimethylsilyl)methyl)cyclohexyl)-2-((R)-3-((S)-1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl)piperidine-1-carboxamido)propyl(methyl)carbamate (79 mg, 0.0991 mmol) and Et4NF (36.9 mg, 0.248 mmol) in dry CH3CN (8 mL) was heated under reflux for 2 h. After the reaction was completed by analysis of HPLC, the mixture was concentrated in vacuo. The product was purified by preparative HPLC to give two isomeric compounds: (3R)-3-((S)-1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl)-N-((2S)-1-(trans-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide (16 mg, 0.0295 mmol) 1H NMR (400 MHz, CD3OD): 2.14 (m, 1H), 2.71 (s, 3H), 3.25 (s, 3H), 3.44-3.49 (m, 1H), 3.94-3.98 (m, 1H), 4.12 (m, 1H), 4.33-4.37 (m, 1H), 7.16-7.11 (t, 1H), 7.33-7.39 (m, 1H), 7.50-7.55 (m, 1H). MS (E/Z): 542 (M+H+) and (3R)-3-((S)-1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl)-N-((2S)-1-(cis-4-hydroxycyclohexyl)-3-(methylamino)propan-2-yl)piperidine-1-carboxamide (10 mg, 0.0185 mmol) 1H NMR (400 MHz, CD3OD): 2.14 (m, 1H), 2.71 (s, 3H), 3.25 (s, 3H), 3.94-4.02 (m, 1H), 4.12 (m, 1H), 4.33-4.37 (m, 1H), 7.16-7.11 (t, 1H), 7.34-7.39 (m, 1H), 7.50-7.54 (m, 1H). MS (E/Z): 542 (M+H+).

Provenance & Evidence