HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-3-(2-methylpropoxy)benzaldehyde → 6-[1-(3-Isobutoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-3-(2-methylpropoxy)benzaldehyde | HCID 2414110 | — |
| Reactant | 6-(Piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride | HCID 42604213 | — |
| Reactant | 6-[1-(4-Methoxy-3-propoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinamide | HCID 42604959 | — |
| Product | 6-[1-(3-Isobutoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinamide | HCID 67400949 | — |
Reaction Steps
The title compound was prepared in analogy to the synthesis of 6-[1-(4-methoxy-3-propoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinamide (example 197) from 6-(piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride (intermediate B7) and 3-isobutoxy-4-methoxy-benzaldehyde (intermediate E12) in a yield of 15.1 mg (21%). MS (ISP): 482.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754744B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-26efb0d8ac6247e0aa6586d2cf439182 |
| Source note | uspto-grants-2010_07 |