HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-[1-(4-Methoxy-3-propoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinamide → 5-[1-(4-Chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyrazine-2-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-[1-(4-Methoxy-3-propoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinamide | HCID 42604959 | — |
| Reactant | 4-Chloro-3-ethoxybenzaldehyde | HCID 54775642 | — |
| Reactant | 5-(Piperidin-4-ylamino)-pyrazine-2-carboxylic acid methyl ester dihydrochloride | HCID 67399609 | — |
| Product | 5-[1-(4-Chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-pyrazine-2-carboxylic acid amide | HCID 67401445 | — |
Reaction Steps
The title compound was prepared in analogy to the synthesis of 6-[1-(4-methoxy-3-propoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinamide (example 197) from 5-(piperidin-4-ylamino)-pyrazine-2-carboxylic acid methyl ester dihydrochloride (intermediate B14) and 4-chloro-3-ethoxy-benzaldehyde (intermediate E2) in a yield of 12.1 mg (21%). MS (ISP): 390.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754744B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-e10e91dbd8bf4f03a4b82ef73bd3eadc |
| Source note | uspto-grants-2010_07 |