HCID 67541838, compound → HCID 86609733, compound

HRID 2355839Notes

Reaction equation

HRID 2355839 reaction equation
BrC1C=[CH:6][C:5]([C@H:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[C@@H:11]3[CH2:19][CH2:20][C:21](=O)[N:10]3[CH2:9]2)=[CH:4][CH:3]=1.C1([C@H:29]2[C:38]3[C:33](=CC=C(O)C=3)[C@@H:32]3[CH2:40][CH2:41][C:42](=O)[N:31]3[CH2:30]2)C=CC=CC=1>>[N:31]1([CH2:42][CH2:41][CH2:40][O:18][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[C@@H:11]2[CH2:19][CH2:20][CH2:21][N:10]2[CH2:9][C@H:8]3[C:5]2[CH:4]=[CH:3][C:8]([C:9]#[N:10])=[CH:5][CH:6]=2)[CH2:30][CH2:29][CH2:38][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 67541838HCID 67541838, compoundHCID 67542831HCID 67542831, compound

Product 1

HCID 86609733HCID 86609733, compound

Procedure

Cis-6-(4-Bromo-phenyl)-8-hydroxy-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one. Prepared as described in Example 42, Step 11, on a 1.89 mmol scale, to yield 654.3 mg of a mixture of the desired product and cis-6-phenyl-8-hydroxy-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one, the product of debromination under the reaction conditions. The crude product was taken on to the next step without purification or characterization.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5aff3aac12d844c5ac352d32c140d0cc
Source dataset
uspto-grants-2010_07
Patent number
US07754882B2

Reaction notes

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