HCID 67542299, compound → HCID 86609733, compound

HRID 2355840Notes

Reaction equation

HRID 2355840 reaction equation
BrC1C=CC([C@H]2C3C(=CC=C(OCCCN4CCCCC4)C=3)[C@@H]3CCC(=O)[N:10]3[CH2:9]2)=CC=1.[C:32]1([C@H:38]2[C:47]3[C:42](=[CH:43][CH:44]=[C:45]([O:48][CH2:49][CH2:50][CH2:51][N:52]4[CH2:57][CH2:56][CH2:55][CH2:54][CH2:53]4)[CH:46]=3)[C@@H:41]3[CH2:58][CH2:59][C:60](=O)[N:40]3[CH2:39]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[N:52]1([CH2:51][CH2:50][CH2:49][O:48][C:45]2[CH:46]=[C:47]3[C:42](=[CH:43][CH:44]=2)[C@@H:41]2[CH2:58][CH2:59][CH2:60][N:40]2[CH2:39][C@H:38]3[C:32]2[CH:33]=[CH:34][C:35]([C:9]#[N:10])=[CH:36][CH:37]=2)[CH2:53][CH2:54][CH2:55][CH2:56][CH2:57]1

Participants

3

Reactant 2

HCID 67542299HCID 67542299, compoundHCID 67542461HCID 67542461, compound

Product 1

HCID 86609733HCID 86609733, compound

Procedure

Cis-6-(4-Bromo-phenyl)-8-(3-piperidin-1-yl-propoxy)-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one. Prepared as described in Example 42, Step 13, on a 1.23 mmol scale to yield 308.1 mg of a mixture of the desired product and cis-6-phenyl-8-(3-piperidin-1-yl-propoxy)-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-49092e8a3ef342069b4ff5f472fce46d
Source dataset
uspto-grants-2010_07
Patent number
US07754882B2

Reaction notes

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