HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2355887Generated: October 25, 2026
Cesium carbonate → Alpha-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-(phenylmethoxy)1(2h)-pyridinepropanoic acid methyl ester
https://huagongshe.com/reaction/2355887
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Benzyloxy-2(1H)-pyridone | HCID 3607724 | — |
| Reactant | Methyl 2-(bis((tert-butoxy)carbonyl)amino)prop-2-enoate | HCID 10870342 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Alpha-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-(phenylmethoxy)1(2h)-pyridinepropanoic acid methyl ester | HCID 58864469 | — |
Reaction Steps
To a solution of 2-(di-tert-butoxycarbonylamino)-acrylic acid methyl ester (900 mg, 3.0 mmol), and 4-benzyloxy-1H-pyridin-2-one (630 mg, 1.03 equiv) in acetonitrile (2.5 mL) was added cesium carbonate (100 mg, 0.10 equiv). The resulting suspension was heated to 80° C. via microwave for 2 h. The reaction was concentrated, dissolved in water, and extracted with methylene chloride (3×). The combined organic phases were washed with brine, dried over magnesium sulfate, and concentrated to give 1.47 g (97%) which was used without purification. Mass spec.: 503.56 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07754732B2 |
|---|
| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-79641440c345421e918459a7951cfbcc |
|---|
| Source note | uspto-grants-2010_07 |
|---|
