反应详情

To a solution of 1-[1,4′]bipiperidinyl-1′-yl-2-(di-tert-butoxycarbonylamino)-3-(4-hydroxy-piperidin-1-yl)-propan-1-one (200 mg, 0.37 mmol) in methylene chloride (4 mL) was added Dess-Martin periodinane (316 mg, 2 equiv) in two portions. After 1 h, the reaction was quenched by the addition of saturated sodium bicarbonate, and extracted into methylene chloride (3×). The combined organic phases were washed with brine, dried over magnesium sulfate, and concentrated to give 187 mg (94%) which was used without purification. Mass spec.: 437.63 (MH)+.

1. customthe reaction was quenched by the addition of saturated sodium bicarbonate
2. extractionextracted into methylene chloride (3×)
3. washThe combined organic phases were washed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customto give 187 mg (94%) which
7. customwas used without purification