HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 5-Boc-1,4,6,7-tetrahydropyrazolo[4,3-C]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | tert-butyl 3-[(dimethylamino)methylene]-4-oxotetrahydro-1(2H)-pyridinecarboxylate | HCID 53395404 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Boc-1,4,6,7-tetrahydropyrazolo[4,3-C]pyridine | HCID 10398680 | — |
Reaction Steps
To a solution of 3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (2.55 g, 10 mmol) in methanol (50 mL) was added hydrazine hydrate (0.61 mL, 1.25 equiv). The solution was heated to reflux, immediately allowed to cool to room temperature, and concentrated to give 1.4 g (63%) which was used without purification. Mass spec.: 224.11 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754732B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-b6e2243cc04644598385a5f7cec7b162 |
| Source note | uspto-grants-2010_07 |