HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356Generated: October 26, 2026
Acrylic Acid → 4-Methoxy cinnamic acid
https://huagongshe.com/reaction/2356
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acrylic Acid | HCID 6581 | — |
| Reactant | 4-Bromoanisole | HCID 7730 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Methoxy cinnamic acid | HCID 13245 | 81.2% |
Reaction Steps
p-bromo anisole (8.4 g), acrylic acid (3.9 g), water (13.5 g), PdCl2 (0.3 mg) and triethyamine (14.3 g, 89.3% pure by titration, the balance being water, recovered by phase separation from a previous run) were charged into an autoclave and heated for 2 hours at 130° C. The work up detailed in Example 1 gave 6.5 g (81%) of >98% pure p-methoxy cinnamic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05728865 |
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| Source dataset | uspto-grants-1998_03 |
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| ORD ID | ord-623e76f5d131438c908eae7b5ce8e7ac |
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| Source note | uspto-grants-1998_03 |
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