HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl 4-(4-oxopiperidin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate | HCID 12717439 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 4-(4-oxopiperidin-1-yl)benzoate | HCID 12717442 | — |
Reaction Steps
A solution of Example 158A (6.31 g, 21.7 mmol) and 30% aqueous acetic acid (100 mL) in THF (50 mL) was stirred at 95° C. for 6 hours, cooled to room temperature, concentrated, treated with water, and extracted with dichloromethane. The combined extracts were washed with water and brine, dried (MgSO4), filtered, and concentrated to provide the desired product. MS (DCI) m/e 248 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754886B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-c3624f870f3d4daea5a1ccfd022ea569 |
| Source note | uspto-grants-2010_07 |