HCID 136042682, compound → HCID 136087745, compound

Participants

Reaction Steps

Pyridinium chlorochromate (1.1 equiv) was added in small portions to a stirred solution of 2-[1-(ethoxyimino)butyl]-3-hydroxy-5-(8-hydroxy-3-methoxy-1-methyl-5,6,7,8-tetrahydroisoquinolin-4-yl)cyclohex-2-en-1-one (0.1 g) in dichloromethane (40 ml) at room temperature. The mixture was filtered through a small silica chromatography column with dichloromethane/ethyl acetate (5:1 v/v) elution to give 2-[1-(ethoxyimino)butyl]-3-hydroxy-5-(3-methoxy-1-methyl-8-oxo-5,6,7,8-tetrahydroisoquinolin-4-yl)cyclohex-2-en-1-one as a white solid, mp 162° C. The product was characterized by proton nuclear magnetic resonance spectroscopy and the spectroscopic data is recorded in Table 4, Example 10.

Provenance & Evidence