Borane;tetrahydrofuran → HCID 22730070, compound

Participants

Reaction Steps

A solution of Example 266A (0.5 g, 2.82 mmol) in TH at room temperature was treated with 1M BH3.THF (15 mL), stirred for 18 hours, quenched with methanol (5 mL), and concentrated. The concentrate was treated with 2M HCl (50 mL) and concentrated. The concentrate was partitioned between dichloromethane and saturated sodium bicarbonate, and the organic phase was dried (MgSO4), filtered, and concentrated to provide the desired product. MS (DCI(+)) m/e 182 (M+H)+.

Provenance & Evidence