HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356113Generated: October 29, 2026
Ammonia → 4-Amino-n-((4'-fluoro-1,1'-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide
https://huagongshe.com/reaction/2356113
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Chloro-n-((4'-fluoro(1,1'-biphenyl)-4-yl)carbonyl)-3-nitrobenzenesulfonamide | HCID 10224907 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Amino-n-((4'-fluoro-1,1'-biphenyl-4-yl)carbonyl)-3-nitrobenzenesulfonamide | HCID 22730356 | — |
Reaction Steps
A solution of Example 1D (1.0 g) in methanol (10 mL) and concentrated aqueous ammonia (3 mL) was heated in a sealed pressure tube to 60° C. for 16 hours, cooled to 0° C., diluted with ethyl acetate (100 mL), washed with water (30 mL) and brine (10 mL), dried (MgSO4), filtered, and concentrated to provide the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07754886B2 |
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| Source dataset | uspto-grants-2010_07 |
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| ORD ID | ord-63f3e0c526814b9aac0a176c2e12c741 |
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| Source note | uspto-grants-2010_07 |
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