Catechol → 2-(Hexyloxy)phenol

Participants

Reaction Steps

A mixture of 740 mL of methyl ethyl ketone, 120 g (1.09 mol) of catechol, 178 g (1.09 mmol) of 1-bromohexane, and 211 g (1.53 mol, 1.4 eq.) of potassium carbonate was refluxed for 25 hours. After being cooled, the mixture was filtered and the solvent was evaporated. The residue of 202 g was purified by silica-gel column chromatography and was then distilled. As a result, 101 g of a transparent liquid was obtained.

Provenance & Evidence