1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 11949716, compound

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2-(4-(2-Chlorophenylsulfonyl)piperazin-1-yl)benzoic acid (76 mg, 0.02 mmole), EDCI (39 mg, 0.02 mmole), HOBt (31 mg, 0.02 mmole) and ammonium formate (13 mg, 0.02 mmole) were combined in 1 ml of dry DMF. The mixture was treated with 1 equivalent of TEA and stirred at room temperature overnight. The title compound was obtained in yield of 37% after purification on preparative HPLC. 1H NMR (400 MHz, DMSO-D6) δ ppm 3.21 (s, 4 H), 3.31 (s, 4 H), 5.87 (br, s, 2 H), 6.68 (s, 1 H), 6.75 (s, 1 H), 6.90 (s, 1 H), 7.26 (s, 1 H), 7.59 (s, 1 H), 7.72 (s, 2 H), 8.02 (s, 1 H); ESI-MS: m/z 380.1 (M+H)+.

Provenance & Evidence