1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 58724206, compound

Participants

Reaction Steps

2-(4-(2-chlorophenylsulfonyl)piperazin-1-yl)thiazole-4-carboxylic acid (77 mg, 0.02 mmole), EDCI (39 mg, 0.02 mmole), HOBt (31 mg, 0.02 mmole) and ammonium formate (13 mg, 0.02 mmole) were combined in 1 ml of dry DMF. The mixture was treated with 1 equivalent of TEA and stirred at room temperature overnight. The title compound was obtained in yield of 37% after purification on preparative HPLC. 1H NMR (400 MHz, CHLOROFORM-D) δ ppm 3.41 (s, 1 H), 3.42-3.44 (m, 3 H), 3.53-3.56 (m, 3 H), 3.57 (s, 1 H), 6.02 (s, 1 H), 6.95 (s, 1 H), 7.38-7.44 (m, 2 H), 7.50-7.53 (m, 2 H), 8.02-8.07 (m, 1 H); ESI-MS: m/z 387.1 (M+H)+.

Provenance & Evidence