反应详情

温度

75 °C

Tert-butyl 4-(methylsulfonyloxy)piperidine-1-carboxylate (2.00 g, 7.16 mmol, prepared according to Blurton et al., WO 00/43362), 2-chlorobenzenethiol (0.898 ml, 7.88 mmol), and potassium carbonate (1.58 g, 11.5 mmol) were stirred together in acetonitrile (15 ml). The reaction was heated to 75° C. and was stirred at that temperature for 15 h. After cooling to room temperature, brine was added, and the mixture was extracted with EtOAc three times. Combined organic layers were dried over MgSO4, filtered and concentrated in vacuo.

1. temperatureAfter cooling to room temperature
2. extractionthe mixture was extracted with EtOAc three times
3. dry with materialCombined organic layers were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo