6-Amino-3-chloropyridazine → HCID 68456032, compound

Participants

Reaction Steps

Sodium (127 mg) was added to a stirred cyclopropylmethanol (5 g). After the sodium had dissolved, 6-chloropyridazin-3-amine (0.648 g) was added and the mixture was heated to 170° in a glass pressure vessel with magnetic stirring for 23 h. The cooled reaction mixture was diluted with water and extracted with chloroform (3×50 mL). The combined extracts were dried (sodium sulfate) and evaporated to afford crude 6-cyclopropylmethoxypyridazin-3-amine (716 mg). 1H n.m.r. (CDCl3) δ 0.27-0.38, m, 2H; 0.52-0.66, m, 2H; 1.18-1.38, m, 1H; 4.18, d, 2H; 4.47 broad s, 2H; 7.78, AB q, 2H.

Provenance & Evidence