Sodium Bicarbonate → HCID 68456328, compound

Participants

Reaction Steps

A stirred mixture of 6-cyclopropylmethoxypyridazin-3-amine (165 mg, 1 mmol), 2-bromo-1-(4-ethoxyphenyl)ethanone (243 mg, 1 mmol) and ethanol (10 mL) was heated under reflux for 3 hours. Sodium hydrogen carbonate (84 mg, 1 mmol) was added and the refluxing was continued for another 3 hours. The mixture was evaporated. The residue was extracted with chloroform (50 mL) and the extract washed with saturated, aqueous, sodium chloride solution (50 mL), dried (MgSO4) and evaporated. The residue was purified by flash chromatography on silica gel. Elution with 1% methanol in dichloromethane afforded Compound 33 (140 mg). 1H n.m.r. (CDCl3) δ 0.30-0.42, m, 2H; 0.60-0.74, m, 2H; 1.20-1.38, m, 1H; 1.40, t, 3H; 4.04, q, 2H; 4.14, d, 2H; 6.70, d, 1H; 6.96, d, 2H; 7.74, d, 1H; 7.80, d, 2H; 7.88, s, 1H.

Provenance & Evidence