Sodium Bicarbonate → HCID 11393767, compound

Participants

Reaction Steps

A solution of 6-propylsulfanylpyridazin-3-amine (169 mg, 1 mmol) and 2-bromo-1-[4-(2-methoxyethoxy)phenyl]ethanone (273 mg, 1 mmol) in ethanol (10 mL) was refluxed for 3 h. Sodium hydrogen carbonate (84 mg, 1 mmol) was then added and the mixture was refluxed for a further 3 h. The solvent was evaporated and the organic residue was extracted with chloroform. The chloroform extract was washed with water, dried (sodium sulfate) and evaporated. The residue was purified by radial chromatography on silica gel. Elution with 2-3% methanol in dichloromethane afforded Compound 65 (57 mg). 1H n.m.r. (CDCl3) δ 1.12, t, J=6 Hz, 3H; 1.75-1.95, m, 2H; 3.16-3.22, m, 2H; 3.27, s, 3H; 3.75-3.82, m, 2H; 4.15-4.22, m, 2H; 6.88-7.08, m, 3H; 7.80-7.995, m, 3H; 8.06, s, 1H.

Provenance & Evidence